As long as it is not a Seagate 7200.9 or 7200.10 (as these do not work in a dual drive configuration)... but as you mention 300GB then I guess it is a Samsung or Western Digital.
Hmm... it will be an interesting test... I can't remember it having been attempted in the past... you may end up having to reimage. You may have to try an un-marry the original drives... although if there was data on the second drive then the MFS database might get upset.
Would be a good idea to document the steps as it could help others if it works.
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